Both previous (Puppin et al. 2011) and this studies demonstrated an upregulation of global histone acetylation by BRAF V600E, which initially seemed to be puzzlingly against our proposed mechanism in which BRAF V600E-mediated downregulation of NIS gene involves deacetylation of histone in thyroid cancer. The gene discussed is BRAF; the disease is thyroid gland carcinoma.