In fact, we demonstrated that the inhibition of HDAC could synergize the inhibitors of BRAF V600E/MAPK pathways to robustly increase thyroid gene expression and radioiodine uptake in thyroid cancer cells (Hou et al. 2010) and even in certain nonthyroid epithelial cancer cells (Hou et al. 2009, Liu & Xing 2012). This evidence concerns the gene BRAF and thyroid cancer.