Collectively, our results obtained with Hdac1Δ/ΔepHdac2Δ/+ep mice are comparable with data published for c-Myc overexpressing mice which display increased proliferation and differentiation along the epidermal and sebaceous lineages at the expense of HF differentiation (Arnold and Watt, 2001; Waikel et al, 2001). The gene discussed is MYC; the disease is hydrops fetalis.