MYC and hydrops fetalis: The phenotype of Hdac1Δ/ΔepHdac2Δ/+ep mice with hyperproliferation of the IFE, increased SG formation and impaired hair development is reminiscent of c-Myc overexpressing mice, which display epidermal hyperproliferation and differentiation along the SG and IFE lineages at the expense of HF development (Arnold and Watt, 2001; Waikel et al, 2001).