Given the extraordinary 2-APB specific electrophysiological profile of hPEC (Figure 3), the low Orai1:Orai3 ratio of ~4 (Figure 1) and Orai3's property to enhance Ca2+ currents upon 2-APB application [44-48] we tested the ability of Orai3 to shape the 2-APB specific electrophysiological profile of ICRAC in the prostate cancer cell line LNCaP as LNCaP are less delicate to patch after transfection than hPEC. Here, ORAI1 is linked to prostate carcinoma.