In addition, a comparison of Orai1:Orai3 gene expression ratios and electrophysiological profiles upon application of 2-APB in prostate cancer cell lines LNCaP, DU145 and hPEC support the idea of low levels of Orai3 in prostate cancer, although Orai3 is not reduced per se in cancer. The gene discussed is ORAI3; the disease is Familial prostate cancer.