The Orai1:Orai3 ratio in prostate cancer cell lines LNCaP und DU145 is elevated compared to hPEC (Orai1:Orai3 = 17±0.9, n = 4, in DU145 and Orai1:Orai3 = 26±0.9, n = 4, in LNCaP calculated from gene expression levels shown in Supplementary Figure 4A). Here, ORAI3 is linked to Familial prostate cancer.