We also found a strong significant difference between groups for all indicators of disease severity at ICU admission (LOD score, SAPS II score, systolic blood pressure, PaO/FiO2, lactates, IL-6 concentrations) suggesting that both isolated ADAMTS13 deficiency and DIC-associated ADAMTS13 deficiency were markers of severity in sepsis. This evidence concerns the gene ADAMTS13 and Sepsis.