A clear association has been demonstrated between genetic variants in genes, such as Contactin-associated protein-like 2 (Cntnap2) and Semaphorin-5A (Sema5A), and ASD, and the localization of rare deletions and duplications has not only led to the identification of new autism candidate genes, such as SH3 and multiple ankyrin repeat domains 3 (Shank3), but also the creation of new mouse models that parallel ASD at both the genetic and behavioral level [11-14]. This evidence concerns the gene SHANK3 and autism.