IL6 and chlamydia trachomatis infectious disease: There were also different IL-6 responses during co-cultures with mononuclear cells from different participant epithelia or lab cell models compared to epithelia alone, in some cases the IL-6 response to Chlamydia was dampened by the co-culture, further supporting that the individual IL-6 response could be a major factor in the modulation of chlamydial infection disease outcome.