Other TFs ranked within the top 20 for liver include Tcf1 and Tcf2, members of the T-cell factor (Tcf) family that are critical for hepatocyte metabolism and function[49,50]; Bhlhb2, which is involved in the regulation of lipogenesis in liver[51]; and Hmbox1, whose expression levels was shown to be reduced in liver cancer compared with surrounding normal tissues[52]. This evidence concerns the gene BHLHE40 and liver cancer.