In agreement with our findings, the ability of redox state fluctuations to affect HIF-1α expression was recently observed in hepatocellular carcinoma cells following inhibition of GSH synthesis by the chemotherapeutic agent buthionine sulphoximine [35], as well as in astrocytes where GSH depletion decreased HIF-1α expression [36]. Here, HIF1A is linked to hepatocellular carcinoma.