In the present study, we have identified Ets-1 as a mediator of glutathione antioxidant capacity in an ovarian cancer model of Ets-1 overexpression, shown that Ets-1 recruits the membrane antiporter Sxc- to increase intracellular GSH levels, and described a potential mechanism to overcome drug resistance in ovarian cancer cells. Here, ETS1 is linked to ovarian cancer.