The etiology of anaemia in HIV infection is multifactorial and typically the anaemia may result from low production of red blood cells, increased RBC destruction, or ineffective RBC production [12] and frequently the laboratory features are compatible with anaemia of chronic disease with a low reticulocyte count, normocytic and normochromic red blood cells with normal iron stores and cytokine mediated poor erythropoietin response [13,14]. This evidence concerns the gene EPO and anemia (phenotype).