EIF4EBP1 and Splenomegaly: We confirmed the impressive reduction of splenomegaly (mean spleen index decreased from 9.0 in the vehicle to 2.3 in treated mice; P < 0.01, Fig. 6D), the decrease of reticulocyte count (from 60 to 29/HPF; P < 0.05, Fig. 6E) and the down-regulation of phosphorylated STAT5 and 4EBP1 (Fig. 6F) as seen in the short treatment set.