AKT1 and myeloproliferative disorder: recently reported profound inhibition of cell proliferation of MPN cell lines and reduced colony formation by primary haematopoietic progenitors of patients with myelofibrosis by using MK-2206, an allosteric inhibitor of AKT; furthermore, they were able to document alleviation of haepatosplenomegaly and reduction of megakaryocyte proliferation in a MPLW515L-driven MPN mouse model 50.