Indeed, we have examined several peptides derived from a variety of cancer-testis antigens that have the oncogenic activity, including KIF20A, DEPDC1, MPHOSPH1, URLC10(LY6K),TTK, KOC1(IMP3), CDCA1, RNF43, and TOMM34 [16,17,20,22-25,27,29]. This evidence concerns the gene RNF43 and cancer.