As a result, in a 4 h RDL-reaction using isolated AML BMMCs as targets and ex vivo expanded MNCs from an unrelated donor as effectors, SPM-2 mediated a significant reduction of the CD34-expressing subset to 15%, down from 89.6% at the start of the reaction (Figure 2C, right panel). Here, CD34 is linked to acute myeloid leukemia.