The regulation of liver ATOH8 levels observed in mice with altered erythropoiesis suggests ATOH8 as a novel physiological regulator of HAMP. ATOH8 may link erythropoietic activity and iron-sensing molecules to HAMP transcription and will open up new avenues of research leading to improved therapies and management of iron overload disorders, such as haemochromatosis and β-thalassaemia. This evidence concerns the gene ATOH8 and hereditary hemochromatosis.