In a gene array study we identified AKIP1 as a differentially expressed gene that was significantly upregulated in animal models of pathological cardiac hypertrophy and heart failure, including pressure overload and post-myocardial infarction (MI) remodelling [11]; however, exercise mediated “physiological hypertrophy” also increased AKIP1 expression [12]. Here, AKIP1 is linked to cardiac hypertrophy.