In case #21, the germline variant observed in MET (T1010I) was confirmed in both cytological and bioptic samples, while an additional EGFR exon 21 L858R mutation was observed only in the biopsy sample (5.5% of analyzed codons), suggesting that the cytological sample did not contain the cancer cells harboring this mutation due to sampling variability. The gene discussed is EGFR; the disease is cancer.