Five weeks of HIT intervention both increases resting and HE-induced IFN-γ/IL-4 ratio (Figure 9C, P<0.05, d=0.8) by decreasing IL-4 (Figure 9A, P<0.05, d=0.8) rather than changing IFN-γ (Figure 9B) level in plasma. Here, IFNG is linked to hereditary elliptocytosis.