IL4 and hereditary elliptocytosis: To answer the above questions, this investigation assessed how HIT (alternating 40% and 80%VO2max) and moderate intensity-continuous training (MCT, sustained 60%VO2max) for 5 weeks affected (i) corresponding biological markers of apoptosis and autophagy, (ii) plasma IFN-γ and IL-4 levels that reflected the regulation of the Th1/Th2 balance, and (iii) pro-inflammatory cytokine and peroxide productions during hypoxic (12%O2) exercise (HE).