Moreover, HE decreased the levels of Atg-12 (Figures 6A-6C, P<0.05) and LC3-II (Figures 6D-6F, P<0.05) in CD4 lymphocytes, which reflected the diminishing elongation of phagophore membrane and subsequent formation of autophagosome. The gene discussed is CD4; the disease is hereditary elliptocytosis.