For example, the Gas6/TAM system appears to have different stage-specific expression not only in metabolic disorders, such as obesity [26] and type-2 diabetes [22], but also in intravascular thromboembolic processes, such as disseminated intravascular coagulation during sepsis [37], in atherosclerotic plaques of human carotid arteries [40] and in acute coronary syndrome [21]. This evidence concerns the gene GAS6 and obesity due to melanocortin 4 receptor deficiency.