As Akt kinase activity is elevated in LNCaP cells [28] and has been significantly correlated with PCa progression [29], to confirm that the changes observed in the 2D profiles depend on modifications of the hnRNP K phosphorylation status, we treated LNCaP cells with Wortmannin, an inhibitor of PI3K/Akt phosphorylation [30]. The gene discussed is AKT1; the disease is posterior cortical atrophy.