TLR2 and Alzheimer disease: According to our results, Wt αSyn-priming additionally affects the Pam3 (TLR2/1)- and ssRNA (TLR7) -stimulated microglia by increasing the secretion levels of the chemokines MCP-1/CCL2 and IP-10/CXCL10, respectively, which have been found to be elevated in the CSF of AD brains from the very early stages of disease and to be linked to neurodegeneration [68].