However, the significance of sIL-2R in sera is complex because CD25 is mainly expressed on activated T-cells and is partially expressed on lymphoma cells in FL and DLBCL; furthermore, there exists CD25-positive DLBCL (Case 10 in Figure 2A) and lymphoma cell also produces MMP-9 (Figure S3 in File S1). This evidence concerns the gene MMP9 and diffuse large B-cell lymphoma.