Particularly in DLBCL, levels of sIL-2R were less than 1000 U/ml even in patients with advanced clinical stage and CD25-positive lymphoma cells (Cases 8, 9 and 10), while levels of sIL-2R were more than 3000 U/ml in patients with advanced clinical stage, but not CD25-positive lymphoma cells (Cases 1, 2 and 5). The gene discussed is IL2RA; the disease is diffuse large B-cell lymphoma.