GLA and Fabry disease: Among them, gross alterations, nonsense mutations, and most of the splicing mutations of the GLA gene lead to a deficiency of the GLA protein, but missense mutations comprising the majority of mutations cause heterogeneous pathogenesis, i.e., some of them affect the active site, while others decrease the stability of the enzyme molecule [2], [3]; thus, the molecular basis of Fabry disease is complex.