TNF and myeloid sarcoma: Pro-inflammatory cytokines, particularly TNF-α, IFN-Υ, IL-1β, IL-6, IL-12 and IL-18, contribute to disruption of the integrity of the blood–brain barrier (Minagar and Alexander 2003) and to induction of CNS neuroinflammation in MS as well as in EAE-rodent models (Imitola et al. 2005).