TBX1 and chordoma: The study enrolled 40 individuals with chordoma, and using whole-exome and Sanger sequencing of T exons, found that a common non-synonymous SNP, rs2305089, of the brachyury gene was a risk factor, with subjects carrying an A allele likely to have a higher risk of developing chordoma (odds ratio [OR] = 5.3; p = 4.6 × 10−12) [9].