Cai et al. [62] showed in a rat model of HF, that epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea that is known to lower NF-κB activity, acts to lower a number of HF associated changes, including elevated connective tissue growth factor levels, elevated collagen and fibronectin synthesis and cell proliferation of cardiac fibroblasts. The gene discussed is CCN2; the disease is hydrops fetalis.