MMP9 and hydrops fetalis: Takimoto et al. showed in a cardiac pressure overload mouse model of HF, that tissue remodeling and a series of changes clearly implicated in remodeling, fibrosis, myocyte hypertrophy, fetal gene expression and MMP-2/MMP-9 expression all increased, as did two measures of oxidative stress and 3-nitrotyrosine [143].