Three reviews of the role of the TRP receptors in HF [195–197] have been published, two of which [195,197] focus mostly on the TRPC group of receptors, particularly TRPC6 and TRPC3, but also including TRPC1 and TRPC4, all of which have substantial causal roles in the mouse model HF. Here, TRPC3 is linked to hydrops fetalis.