2% of the cases of chronic hepatitis B with B19 DNA were detected in 37% of the cases of chronic hepatitis B. In cases of chronic hepatitis C, IgM and IgG antibodies for B19 were positive in 15.7% and 70.6%, and B19 DNA was detected in 23.5% of HCV cases. Here, CD40LG is linked to chronic hepatitis B virus infection.