Intriguingly, BRD4 was shown to bind to histones in the MYC promoter region itself and play a critical role in MYC expression in human cancer cells such that inhibition of BET with JQ1 resulted in a remarkable diminution of MYC expression, decreased BRD4 binding to the MYC promotor and associated cell death [20, 21]. This evidence concerns the gene MYC and cancer.