However, in node negative patients, immunohistochemistry study has shown that both fibroblastic PAI1 and diffuse stromal uPA are associated with local recurrence [48] and even though fibroblastic expression of uPA and uPAR (urokinase-type plasminogen activator receptor) and strong PAI1 expression was related to the presence of invasion or tumour size, it was not associated with node metastasis [31]. Here, SERPINE1 is linked to neoplasm.