More specifically, increased IgM and IgA responses to LPS in depression are significantly and positively correlated to plasma lysozyme, serum oxidized LDL antibodies and the IgM responses directed against azelaic acid and malondialdehyde and phosphatidylinsositol, and NO-adducts, such as NO-tryptophan and NO-tyrosine [140]. Here, CD40LG is linked to major depressive disorder.