The authors also indicated several possible mechanisms for the reduction of PON1 level in rheumatoid arthritis: consumption/inactivation of antioxidant PON1 property under the disease with inflammation and oxidative stress, the influence of structural/compositional and functional changes of HDL particles modified by inflammation and oxidative stress on the active sites of PON1, a rapid clearance of PON1 during inflammation, and/or a disturbance of PON1 production by the liver at the transcriptional level during inflammation [12]. This evidence concerns the gene PON1 and rheumatoid arthritis.