The multivariate general linear model revealed significant main effects for cardiovascular risk (F = 4.41, df = 7,14, P = 0.009) and MMSE score (F = 9.15, df = 7,14, P < 0.001) but not for APOE genotype, family history of Alzheimer's disease, and age. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.