Although SOD1-linked familial ALS is relatively rare, evidence suggests that wtSOD1 can also misfold, leading to the surface exposure of similar misfolding-specific epitopes, and may be a contributing factor to sporadic ALS, due to the presence of misfolded wtSOD1 in the spinal cord of sporadic ALS patients [221–225]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.