Nonetheless, the demonstrated variability at phosphorylated protein levels among OLP cases may indicate that a minority of OLPs do possess exuberant Akt/mTOR/pS6 signaling activity (manifested by positivity for p-Akt and p-mTOR and higher levels of phosphor-pS6), which could contribute to their premalignant potential. This evidence concerns the gene MTOR and oral lichen planus.