The purpose of this study was to assess the immunohistochemical expression of the phosphorylated (activated) forms of Akt, mTOR, and pS6 in biopsy samples of OLP in comparison with oral leukoplakia (OL) with various degrees of dysplasia, oral squamous cell carcinoma (OSCC), and control cases of normal mucosa (NM), in order to evaluate the potential contribution of Akt/mTOR/pS6 signaling pathway aberrations in OLP malignant potential. This evidence concerns the gene AKT1 and oral cavity squamous cell carcinoma.