MKI67 and cancer: Figure 5 shows representative 3D images of Ki67-positive (red) and Ki67-negative (green) nuclei in discohesive cancer foci. The smallest consisted of a single CK-positive cell with a Ki67-negative nucleus, while the largest analyzed so far included a total of 1,292 nuclei, comprising 277 Ki67-positive and 1,015 Ki67-negative nuclei. It is important to note that the majority (68%) of discohesive cancer foci with diameters <25 μm contained only a few cancer cells.