ANO3 and schizophrenia: In schizophrenia, the associated SNP in NALCN was rs2044117, located at the last intron.26 The C-terminal end of the protein is the important site in coupling with UNC79 and UNC80 proteins.27 This complex senses calcium level and results in alteration of leaking current and neuronal excitability, comparable to ANO3 as a calcium-gated chloride channel.