GSDMB and asthma: The asthma association on the 17q21 region was one of the first cases of explicitly using expression data to interpret disease association, with the association with asthma initially attributed to ORMDL3 based on expression data from EBV transformed cell lines [Moffatt et al., 2007] and subsequently to GSDMB from a reanalysis of the same data [Moffatt et al., 2010].