On the basis of cut-off score, HERC4 positive expression was detected in 1/16 (6.3%) of normal breast tissue, in 3/13 (23.1%) of fibroadenoma, in 6/15 (40%) of intraductal carcinoma and 66/120 (55%) of invasive ductal carcinoma (Table 1, p < 0.05, χ2-test). Here, HERC4 is linked to ductal breast carcinoma in situ.