OTX2 and Alzheimer disease: Specific gene expression profiles of neurogenesis in AD treatment have not been clearly identified, although according to Gene Ontology [53] classification, the upregulation of five genes in the HA line (Sema3F, Ntng1, Gbx2, Efna5, Rora) and three genes in the LA line (Otx2, Rarb, Drd1a) involved in neurogenesis, neurite outgrowth, and the proliferation and differentiation of neuronal progenitor cells were detected.