Since the first-line drugs used in the treatment of colon cancer (e.g. irinotecan, oxaliplatin, 5-fluorouracil) are not substrates of BCRP, we do not believe that the increase of BCRP may negatively affect the outcome of patients subjected to the standard chemotherapeutic regimen for colon cancer. This evidence concerns the gene ABCG2 and malignant colon neoplasm.