SREBF2 and malignant colon neoplasm: In colon cancer cells, the effects of ω3PUFAs are more controversial: for instance, EPA inhibits HMGCoAR activity in CaCo-2 colon cancer cells[22]; DHA has little effect on the de novo synthesis of cholesterol in SW620 cells[23], although it increases the sterol regulatory element binding protein-2 (SREBP-2), which induces the transcription of several genes involved in the cholesterol synthesis - e.g. HMGCoAR and 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCoAS)[23,24].