TNF and acute respiratory distress syndrome: In another study using LPS-initiated ALI in mice, epigallocatechin-3-gallate demonstrated an anti-inflammatory effect by reducing neutrophil recruitment in the lung and the production of TNF-α and macrophage inflammatory protein (MIP)-2, most likely via reduced extracellular-signal-regulated kinase (ERK)1/2 and c-Jun N-terminal kinase (JNK) phosphorylation in the lungs [63].