The overall allelic frequency of all TREX1 rare variants (Minor Allele Frequency < 1%) in SS patients (4/58) is statistically higher than in the 4300 healthy European American individuals from the Exome Variant Server (Peto's OR = 27.2, 95% CI = 3.5–208.8, Fisher's exact test 2-tailed P value = 0.025). Here, TREX1 is linked to synovial sarcoma.