AQP3 and hepatocellular carcinoma: According to the results, we found that the expression levels of AQP3 protein in HCC tissues with the higher tumor stage (T3~4) and the positive serum AFP level were significantly lower than those with the lower tumor stage (T1~2, P = 0.005, Table 1) and the negative serum AFP level (P = 0.002, Table 1), respectively.