Guo et al. [15] found that the expression of AQP5 was significantly decreased ovarian cancer; High expression level of AQP3 was also observed by Kusayama et al. [18] in tumor areas of human primary squamous cell carcinoma such as esophageal and lingual cancers, and lymph node metastasis, but it was not observed in normal areas. The gene discussed is AQP3; the disease is squamous cell carcinoma.