AQP5 and ovarian cancer: Guo et al. [15] found that the expression of AQP5 was significantly decreased ovarian cancer; High expression level of AQP3 was also observed by Kusayama et al. [18] in tumor areas of human primary squamous cell carcinoma such as esophageal and lingual cancers, and lymph node metastasis, but it was not observed in normal areas.