CXCL8 is a proinflammatory chemokine that acts on leukocytes and endothelial cells, via their CXCR1 and CXCR2 receptors, to promote immune infiltration and angiogenesis, which in turn establishes a venue for cancer cell local invasion, migration, and metastasis [26]. This evidence concerns the gene CXCR2 and cancer.