KLK3 and neoplasm: Traditionally, clinicians may have been more likely to treat patients with androgen deprivation if clinicopathologic features were associated with high risk of systemic disease (e.g. immediately detectable PSA, seminal vesicle invasion, or high Gleason score) and more likely to treat patients with adjuvant or salvage radiotherapy if features were associated with high risk of isolated localized disease (e.g. late PSA recurrence, positive surgical margin, extraprostatic tumour extension, and low Gleason score) [15].