However, high levels of TG might negatively affect cognitive function by other mechanisms, one of which could be through hippocampal insulin resistance [15], and another by decreasing the ability of leptin to cross the blood-brain-barrier resulting in low leptin levels, which might diminish cognitive function [55] or by impairing the NMDA (N-methyl-D-aspartate) component of hippocampal long-term potentiation [28]. The gene discussed is LEP; the disease is Insulin resistance.