Interestingly, NGF production by B cells tended to be higher in SLE patients with cryoglobulinemia (mean fluorescence intensity, Xmean, 8.7 ± 7.7) than in patients without cryoglobulinemia (Xmean 4.1 ± 2.7, p=0.06). Here, NGF is linked to cryoglobulinemia.