SHMT2 and hepatocellular carcinoma: In order to validate our findings from the DIGE-based proteomics analysis, we analyzed the protein expression of mSHMT in MDA-MB-468 as well as in two other high Arg II expressing HCC1806 and HCC 70 cell lines treated either with NOHA (1mM) alone or in combination with L-ornithine (0.5mM) after 48 hrs.