Here 6 studies with a total of 1,333 cases and 3,011 controls were analyzed for the PAI-1 -675 4G/5G polymorphism with diabetes risk [11,12,19,22,24,27], 7 studies with 1,060 cases and 1,139 controls for this polymorphism with DN [11-14,19,23,26,], 10 studies with 1,327 cases and 1,557 controls for DR [9-11,14,15,18-21,25] and 4 studies with 610 cases and 1,042 controls for diabetic CAD risk [8,16,17,20] respectively. The gene discussed is SERPINE1; the disease is diabetes mellitus.