Our meta-analysis revealed no association between the PAI-1 -675 4G/5G polymorphism and diabetes risk, either by allelic comparision (REM OR 1.07, 95% CI 0.96, 1.20), dominant (REM OR 1.16, 95% CI 0.96, 1.40), recessive (REM OR 1.04, 95% CI 0.88, 1.24) or co-dominant (REM OR 1.18, 95% CI 0.94, 1.47) models. The gene discussed is SERPINE1; the disease is diabetes mellitus.