In a phase II study conducted within the last couple of years which evaluated the effect of HGF antibody and MET pathway biomarkers in advanced GC patients[15], the scoring criteria developed by Kelly et al. identified high c-Met expression as percentage of cells staining≥50% as well as staining intensity grade≥1 for the stained slides, and the total number of MET gene copy>15 for FISH. The gene discussed is HGF; the disease is gastric cancer.