A subtype of LDH, LDH-A, is up-regulated in glioma cells [3] which leads to production of the enzymes LDH IV and V, that mainly metabolize pyruvate to lactate, whereas higher expression of LDH-B leads to formation of LDH I, II and III catalysing the oxidation of lactate to pyruvate. This evidence concerns the gene LDHA and glioma.