INS and major depressive disorder: When examining the Kaplan-Meier curves, we also did not observe a difference in time to insulin initiation for both groups (log-rank test X2[1] = 0.01, p = 0.92), with a mean time to event of 1,783 (95% CI 1,758–1,807) and 1,749 (95% CI 1,671–1,828) days for those without and with depression, respectively (Figure 1).